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Old 01-11-2012, 07:53 PM   #1
SoHappy
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Well, there goes Dr. Johnson's Resveratrol business

Did any of you see the following article. Looks like this stuff may be even more suspect than many felt before this revelation. Being elevated and heralded based on faulty and altered research sort of casts a lot of suspicion and doubt on whether this stuff has any worth and value in the least. What stupidity on this researcher's part.

HARTFORD, Conn. — A University of Connecticut researcher known for his work on red wine's benefits to cardiovascular health falsified his data in more than 100 instances, and nearly a dozen scientific journals are being warned of the potential problems after publishing his studies in recent years, officials said Wednesday.

UConn officials said their internal review found 145 instances over seven years in which Dr. Dipak Das fabricated, falsified and manipulated data, and the U.S. Office of Research Integrity has launched an independent investigation of his work.

Das, a tenured surgery professor and director of UConn Health Center's Cardiovascular Research Center, has gained national attention in recent years for research into the beneficial properties of resveratrol, which is found in red wine.

It wasn't immediately known Wednesday whether the irregularities in Das' research were significant enough to alter the conclusions, but the cardiovascular benefits of resveratrol have also been established in other researchers' work.

Eleven scientific research journals that have published Das' work are being notified of the problems, which came to light after a three-year review sparked by an anonymous complaint in 2008 of potential irregularities in his research.

"We have a responsibility to correct the scientific record and inform peer researchers across the country," Philip Austin, interim vice president for health affairs, said in a written statement about the notifications to the 11 scientific journals.

The university's health center recently declined to accept $890,000 in federal grants awarded to Das as its review was under way, and has frozen all other external funding for his lab.

Dismissal proceedings have also been launched against Das, who has been employed by the Health Center since 1984 and was granted tenure in 1993. Das could not immediately be reached Wednesday, and messages were left for him through the union representing him.

Das' other specialty areas besides resveratrol include medicines derived from plants, the molecular structure of plants and herbs and their effect on heart disease, and a nutrient found in Vitamin E that has shown promise fighting free radicals.

He also gained attention in 2009 after publishing a study that concluded crushed garlic provided protection for heart health than processed garlic.

The U.S. Office of Research Integrity received the anonymous tip about potential irregularities in a paper by Das about resveratrol and notified UConn, which set up a special review committee that reviewed six years' worth of his work.

Its report found what it called "a pervasive attitude of disregard within the (lab)" for commonly accepted scientific practices.

It also said there were so many problems— and over so many years — that the review board members "can only conclude that they were the result of intentional acts of data falsification and fabrication, designed to deceive."

Some examples included several cases in which data was digitally altered; data from one experiment was used to justify findings in another; and controls from one experiment were used to denote another experiment's controls, which are the unchanged factors against which experiments are compared.

Austin, the UConn health affairs vice president, said they are "deeply disappointed by the flagrant disregard" for UConn's conduct codes, but grateful that the anonymous tipster notified authorities.

"The abuses in one lab do not reflect the overall performance of the Health Center's biomedical research enterprise, which continues to pursue advances in treatments and cures with the utmost of integrity," Austin said. "We demand full compliance with all research standards and policies by our faculty and staff."

The disclosure comes less than a week after Connecticut authorities finalized an agreement with a Maine-based lab to build a genomic research facility at the UConn Health Center in Farmington as part of a broader plan to expand the medical and dental schools and boost research.

Das' research pre-dates those plans by several years, and is not directly part of the genomic research program.
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Old 01-11-2012, 08:53 PM   #2
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Bad science makes me so angry.
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Old 01-12-2012, 05:03 AM   #3
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Thanks for the post. Geeze.
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Old 01-12-2012, 05:53 AM   #4
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Old 01-12-2012, 06:19 AM   #5
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Well, dang.

Wouldn't it be wonderful if science actually was the pursuit of truth?

I was about to take a Res. What to do? What to do?
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Old 01-12-2012, 06:30 AM   #6
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Was Dr. Das the main researcher behind all the claims of benefits from resveratrol? I know that Dr. Johnson claims there were studies showing the benefits, but I didn't see the actual studies to which he referred.

In other words, maybe there are benefits from resveratrol?
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Old 01-12-2012, 07:06 AM   #7
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Quote:
Originally Posted by Emily-D View Post
Was Dr. Das the main researcher behind all the claims of benefits from resveratrol? I know that Dr. Johnson claims there were studies showing the benefits, but I didn't see the actual studies to which he referred.

In other words, maybe there are benefits from resveratrol?
I strongly suspect that all the studies showing the benefits were those run by this Das jerk.

And call me a skeptic, but I also strongly suspect the biggest benefit from resveratrol is that it doesn't hurt you to consume it.
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Old 01-12-2012, 07:11 AM   #8
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Well it still should be a decent anti-oxidant? There have been a lot of other studies over the years that say various colored fruits and veggies have a load of nutritional benefits. Grape extract should be the same, I'd think.
It's a shame something like this has to muddy the waters when consumers just want the truth.
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Old 01-12-2012, 07:11 AM   #9
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I just hate it when somebody in research gets some idea and then sets out to prove it:

Ah, in countries where they are known (even stereotypically) to drink a lot of red wine, like... oh... say France... they have a lower incidence of heart attack than we do in the U.S. !! I'll bet it's something in the red wine that makes the difference.

And then they pursue that bright single idea they've manufactured in their own head, and *prove* it. By whatever little means necessary. By hook or by crook... they get the study results they're after, and prove that they were right! Great breakthrough!
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Old 01-12-2012, 07:13 AM   #10
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Quote:
And call me a skeptic, but I also strongly suspect the biggest benefit from resveratrol is that it doesn't hurt you to consume it.
I strongly suspect that the biggest benefit of Resveratrol is lining the pockets of those who make health claims and sell the stuff.
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Old 01-12-2012, 07:16 AM   #11
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This is disheartening for research. It's hard enough as a consumer when it seems like one study says this, another study says the opposite (example - eggs are bad. No, eggs are good.)

I never took resv. as a supplement, but I sure have supplemented it via vino!
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Old 01-12-2012, 07:17 AM   #12
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Good to know - I was considering adding it to my supplement line-up.
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Old 01-12-2012, 12:57 PM   #13
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I ran across Das' name many times when I researched res. Which puts it's status as a particularly wonderful anti-oxidant in question too. When will science learn that the point is not to prove what you have already decided is true???
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I did not "lose" weight. I evicted it. It is gone and it ain't coming back!

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Old 01-12-2012, 07:05 PM   #14
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Yep so glad I didnt buy it, I do have a multi with it in there but will consider it an antioxidant lol
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Old 01-12-2012, 08:37 PM   #15
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Originally Posted by gotsomeold View Post
I ran across Das' name many times when I researched res. Which puts it's status as a particularly wonderful anti-oxidant in question too. When will science learn that the point is not to prove what you have already decided is true???
Real science doesn't work this way and real, ethical scientist don't work this way. The worst part of things like this is it makes the general public doubt the scientific method and how it is supposed to work. Grrr...again, bad science makes me so angry!
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Old 01-13-2012, 05:55 AM   #16
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It is unfortunate that this happened, but from a couple of articles I read, other research also found benefits from taking in extra resveratrol, so I would stop if you are already taking it. I take mine in a glass or two of red wine a night, and I'm not about to stop!
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Old 01-13-2012, 06:55 AM   #17
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I actually work at UConn (it's a huge institution and I have no connection with this individual!) and this sent shock waves through the entire community yesterday. Shocking, dangerous and irresponsible
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Old 01-13-2012, 07:01 AM   #18
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I drank red wine before I heard about reversatrols. I'll continue drinking it.

But I'm glad I didn't invest in supplements. What a shame that scientists would falsify data like that. But then, that's why studies are published; so other scientists can duplicate the experiments and see if they get the same results. Science isn't exact, and one study (or multiple studies by the same group) does not a science fact make.
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Old 01-13-2012, 08:02 AM   #19
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I actually work at UConn (it's a huge institution and I have no connection with this individual!) and this sent shock waves through the entire community yesterday. Shocking, dangerous and irresponsible
I'm sorry.
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