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-   -   Scientific American article on possible benefits of ketosis on brain function (http://www.lowcarbfriends.com/bbs/recommended-reading/814566-scientific-american-article-possible-benefits-ketosis-brain-function.html)

Ntombi 10-11-2013 03:53 AM

Scientific American article on possible benefits of ketosis on brain function
The Fat-Fueled Brain: Unnatural or Advantageous? | MIND Guest Blog, Scientific American Blog Network

Some excerpts:


In a model of epilepsy that used a chemical similar to glutamate to induce damage, the diet protected mice against cell death in the hippocampus by inhibiting pro-death signaling molecules. On the other end of the excitation-inhibition balance, ketones increase GABA in the synapses (where neurotransmitters are released) of rats and in the brains of some (but not all) epileptic humans subjects. This increase in inhibition may confer both anti-seizure effects and neuroprotection, though data is still scant.


A study with 23 elderly with mild cognitive impairment showed that a ketogenic diet improved verbal memory performance after 6 weeks compared to a standard high carbohydrate diet. In a double-blind, placebo-controlled study, 152 patients with mild- to moderate Alzheimer’s disease were given either a ketogenic agent or a placebo, while maintaining a normal diet. 90 days later, those receiving the drug showed marked cognitive improvement compared to placebo, which was correlated with the level of ketones in the blood.

In a pilot study in 7 patients with Parkinson’s disease, 5 were able to stick to the diet for 28 days and showed marked reduction in their physical symptoms. In an animal model of Amytrophic Lateral Sclerosis (ALS), a ketogenic diet also led to delayed motor neuron death and histological and functional improvements, although it did not increase life span; clinical trials are on the way.

AnnetteW 10-11-2013 05:48 AM

Thanks. I'll check the article out when I get home.

In a few years the same article will be in Time Magazine, and it will be all the new rage...lol.

Ntombi 10-12-2013 04:50 AM

Too true. :doh:

Mistizoom 10-13-2013 07:11 PM

Cool, thanks for the recommendation. The book Grain Brain by David Perlmutter also focuses on the benefits of a ketogenic diet on the brain.

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