Low Carb Friends  
Netrition.com - Tools - Reviews - Faces - Recipes - Home


Go Back   Low Carb Friends > Inspiration and Wisdom > Recommended Reading
Register FAQ Search Today's Posts Mark Forums Read


Reply
 
LinkBack Thread Tools Display Modes
Old 08-14-2011, 06:09 PM   #1
Blabbermouth!!!
 
Portia's Avatar
 
Join Date: Mar 2005
Location: The beautiful North Shore
Posts: 5,960
Gallery: Portia
WOE: Low Carb
Start Date: May 1, 2014
BBC News - fat "disrupts sugar sensors causing Type II Diabetes"


Type 2 diabetes 'can be reversed'
Diabetes rate 'doubles' worldwide

US researchers say they have identified how a high-fat diet can trigger type 2 diabetes, in experiments on mice and human tissue.

Writing in the journal Nature Medicine, they say that fat interferes with the body's sugar sensors.

The authors argue that a deeper understanding of the processes involved could help them develop a cure.

Diabetes UK said the study was interesting and a "theory worth investigating further".

One of the main risk factors for type 2 diabetes is being overweight - rising obesity levels have contributed to a doubling of diabetes cases in the last 30 years.
Fat and sugar

Sugar in the blood is monitored by pancreatic beta cells. If sugar levels are too high then the cells release the hormone insulin, which tells the body to bring the levels back down.

Key to this is the enzyme GnT-4a. It allows the cells to absorb glucose and therefore know how much is in the blood.
Continue reading the main story
“Start Quote

The identification of the molecular players in this pathway to diabetes suggests new therapeutic targets and approaches towards developing an effective preventative or perhaps curative treatment”

Dr Jamey Marth Lead researcher

Researchers at the University of California and the Sanford-Burnham Medical Research Institute say they have shown how fat disrupts the enzyme's production.

Experiments on mice showed that those on a high-fat diet had elevated levels of free fatty acids in the blood.

These fatty acids interfered with two proteins - FOXA2 and HNF1A - involved in the production of GnT-4a.

The result: fat effectively blinded cells to sugar levels in the blood and the mice showed several symptoms of type 2 diabetes.

The same process also took place in samples of human pancreatic cells.

Lead researcher Dr Jamey Marth said: "The observation that beta cell malfunction significantly contributes to multiple disease signs, including insulin resistance, was unexpected."

He suggested that boosting GnT-4a levels could prevent the onset of type 2 diabetes: "The identification
[/I] of the molecular players in this pathway to diabetes suggests new therapeutic targets and approaches towards developing an effective preventative or perhaps curative treatment.

"This may be accomplished by beta cell gene therapy or by drugs that interfere with this pathway in order to maintain normal beta cell function."

Dr Iain Frame, Director of Research at Diabetes UK, said: "This is a well-executed study into possible factors responsible for the events that lead to type 2 diabetes.

"The researchers have linked their results in mice to the same pathways in humans and although they did not show they could prevent or cure type 2 diabetes they have shown it is a theory worth investigating further.

"We will watch this with great interest and hope this early work will eventually lead to some benefit to people with type 2 diabetes."[/I]

Does anyone know anything about the funding for/authors of the study?

Let's discuss!
__________________
Jes

Portia's Journal
Portia is offline   Reply With Quote

Sponsored Links
Old 08-14-2011, 06:19 PM   #2
Major LCF Poster!
 
poopsie2223's Avatar
 
Join Date: Jan 2009
Location: Colorado Rockies
Posts: 1,260
Gallery: poopsie2223
Stats: 5'-8" - 209/197/145
WOE: Atkins
Start Date: Since 1998 restarted 08/08/11
Oh no. The press will be all over this telling everybody to go on low fat diets.
poopsie2223 is offline   Reply With Quote
Old 08-14-2011, 06:33 PM   #3
Major LCF Poster!
 
kat819's Avatar
 
Join Date: Jun 2010
Location: Washington, DC
Posts: 1,555
Gallery: kat819
Stats: 263/227/163 5'9"
WOE: PaNu/very low carb
Start Date: 1st time 9/2003, third time's the charm 5/13/2010
That makes no sense given that Type II diabetics need to eat a high fat diet to adequately control their blood sugar without drugs. Maybe it's only true if you're eating high fat/high carb.
kat819 is offline   Reply With Quote
Old 08-14-2011, 06:36 PM   #4
Major LCF Poster!
 
vilanteira's Avatar
 
Join Date: Jul 2011
Posts: 1,067
Gallery: vilanteira
Stats: in maintenance
WOE: juddd/lower carb
Start Date: low carb: 2008, juddd: 10/24/11
I'm having difficulty understanding how this makes sense or how they came to this conclusion.
vilanteira is offline   Reply With Quote
Old 08-14-2011, 06:48 PM   #5
Blabbermouth!!!
 
Portia's Avatar
 
Join Date: Mar 2005
Location: The beautiful North Shore
Posts: 5,960
Gallery: Portia
WOE: Low Carb
Start Date: May 1, 2014
Impossible to tell if it was high fat and high carb, or high fat and low carb. I assume they controlled for carbs so they could isolate fat, otherwise it would be a useless study.
Portia is offline   Reply With Quote
Old 08-14-2011, 07:12 PM   #6
Major LCF Poster!
 
poopsie2223's Avatar
 
Join Date: Jan 2009
Location: Colorado Rockies
Posts: 1,260
Gallery: poopsie2223
Stats: 5'-8" - 209/197/145
WOE: Atkins
Start Date: Since 1998 restarted 08/08/11
Quote:
Originally Posted by Portia View Post
Impossible to tell if it was high fat and high carb, or high fat and low carb. I assume they controlled for carbs so they could isolate fat, otherwise it would be a useless study.
But if they controlled carbs, how could they tell that fat was somehow messing with sugar metabolism? If there was no sugar to metabolize, there would be nothing to measure.
poopsie2223 is offline   Reply With Quote
Old 08-14-2011, 07:18 PM   #7
Way too much time on my hands!
 
metqa's Avatar
 
Join Date: Oct 2002
Location: Athens, GA
Posts: 12,656
Gallery: metqa
Stats: 147/136/125; 5'1"
WOE: PSMF/hcg Transitioning to HFLC
Start Date: joined LCF 2003: HCG/PSMF 07/2014
much of history is based on useless study. Just look at Ancel Keys. He claimed he looked at the lipid Hypothesis based study from the point of holding fat steady and got the results he did, but he did not go back and analyze holding sugar the same way. He just assumed sugar was only a problem when fat was high. That was a useless study and our entire countries food recommendations are based on it.
metqa is offline   Reply With Quote
Old 08-15-2011, 02:48 PM   #8
Major LCF Poster!
 
Aomiel's Avatar
 
Join Date: Oct 2010
Posts: 2,569
Gallery: Aomiel
Stats: 330/140/140 A1c 4.8
WOE: Bernstein (Maintenance)
Start Date: January 2010
They seriously need to do a study on people who *consistently* eat a high fat, low carb (under 60gm per day) diet before they make come to these stupid conclusions. I eat a high fat, low carb diet and it's the only reason I no longer take insulin and my A1C is now down at 5.5.

.
Aomiel is offline   Reply With Quote
Old 08-15-2011, 03:17 PM   #9
Senior LCF Member
 
Join Date: Jun 2011
Location: Southern USA
Posts: 399
Gallery: cocoanut
Stats: 274/215/140 5'4"
WOE: VLC to prevent diabetes
Start Date: Feb 2011
This is not a new idea. Note the reference to a "high-fat, Western-style diet". Also note in the 2nd paragraph reference to an article in 2005.


"Howard Hughes Medical Institute researchers have discovered a molecular link between a high-fat, Western-style diet, and the onset of type 2 diabetes. In studies in mice, the scientists showed that a high-fat diet interferes with a genetic mechanism they discovered that promotes insulin production, resulting in the classic signs of type 2 diabetes.

In an article published in the December 29, 2005, issue of the journal Cell , the researchers report that knocking out a single gene encoding the enzyme GnT-4a glycosyltransferase (GnT-4a) disrupts insulin production. Importantly, the scientists showed that a high-fat diet suppresses the activity of GnT-4a and leads to type 2 diabetes due to failure of the pancreatic beta cells. "
cocoanut is offline   Reply With Quote
Old 08-15-2011, 05:27 PM   #10
Blabbermouth!!!
 
Portia's Avatar
 
Join Date: Mar 2005
Location: The beautiful North Shore
Posts: 5,960
Gallery: Portia
WOE: Low Carb
Start Date: May 1, 2014
Quote:
Originally Posted by poopsie2223 View Post
But if they controlled carbs, how could they tell that fat was somehow messing with sugar metabolism? If there was no sugar to metabolize, there would be nothing to measure.
By that I meant "controlled for" carbs, not controlled carbs. In other words, they made sure that carbs were not a factor.
Portia is offline   Reply With Quote
Old 08-15-2011, 06:27 PM   #11
Major LCF Poster!
 
Join Date: Jul 2008
Location: MA
Posts: 1,013
Gallery: nanberrycritter
Stats: 315/283/135 5'5" age 42 (scale-free since Dec)
WOE: LC primal + raw dairy
Start Date: ketogenic since Dec 20, 2010
What kind of fat was used in the study? That's what I'd like to know. Was it soybean, corn or canola oil? Or was it saturated fat from dairy, beef, coconuts? I know I'm getting better results this round of lowcarbing it since I ditched the rancid omega-6 laden oils but have lots of yummy tasty saturated fat from clean sources.
nanberrycritter is offline   Reply With Quote
Old 08-16-2011, 05:42 AM   #12
Blabbermouth!!!
 
Portia's Avatar
 
Join Date: Mar 2005
Location: The beautiful North Shore
Posts: 5,960
Gallery: Portia
WOE: Low Carb
Start Date: May 1, 2014
I'm hoping someone will weigh in who has more details. Checking the Eades blog as well.
Portia is offline   Reply With Quote
Reply


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are On



All times are GMT -7. The time now is 05:38 PM.


Copyright ©1999-2014 Friends Forums LLC. All rights reserved. - Terms of Service | Privacy Policy
LowCarbFriends® is a registered mark of Friends Forums, LLC.