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Bobby_Boomer 06-30-2011 02:26 PM

█ Low Carbohydrate, High Protein Diet Slows Tumor Growth & Prevents Cancer Initiation
 
From the US Government National Institute of Health (NIH):

Abstract

Since cancer cells depend on glucose more than normal cells, we compared the effects of low carbohydrate (CHO) diets to a Western diet on the growth rate of tumors in mice. To avoid caloric restriction-induced effects, we designed the low CHO diets isocaloric with the Western diet by increasing protein rather than fat levels because of the reported tumor-promoting effects of high fat and the immune-stimulating effects of high protein. We found that both murine and human carcinomas grew slower in mice on diets containing low amylose CHO and high protein compared with a Western diet characterized by relatively high CHO and low protein. There was no weight difference between the tumor-bearing mice on the low CHO or Western diets. Additionally, the low CHO-fed mice exhibited lower blood glucose, insulin, and lactate levels. Additive antitumor effects with the low CHO diets were observed with the mTOR inhibitor CCI-779 and especially with the COX-2 inhibitor Celebrex, a potent anti-inflammatory drug. Strikingly, in a genetically engineered mouse model of HER-2/neu-induced mammary cancer, tumor penetrance in mice on a Western diet was nearly 50% by the age of 1 year whereas no tumors were detected in mice on the low CHO diet. This difference was associated with weight gains in mice on the Western diet not observed in mice on the low CHO diet. Moreover, whereas only 1 mouse on the Western diet achieved a normal life span, due to cancer-associated deaths, more than 50% of the mice on the low CHO diet reached or exceeded the normal life span. Taken together, our findings offer a compelling preclinical illustration of the ability of a low CHO diet in not only restricting weight gain but also cancer development and progression.


Sounds like people are finally getting the message!

Bobby

errihu 06-30-2011 02:47 PM

Finally. But they should test whether high fat is actually a factor too - instead of assuming that high fat is a factor. I would have done the following groups:

SAD control with no removed or added fat,

SAD with added fat,

SAD with removed fat,

Low carb with added fat at the same ratio as SAD,

Low carb with removed fat (the protein they use above),

and compare all five groups. This would control for the effects of fat and maybe weigh in on whether or not low carb is any more or less helpful as a cancer suppressant with fat.

snowmop 06-30-2011 04:38 PM

I've never before heard that high fat is "reported" to promote tumors!!! Anyone know about that???

Bobby_Boomer 07-01-2011 07:16 AM

+1 on the errihu post.

All this test does is suggest that high carbohydrates feed cancers. It says nothing about fat.

Bobby


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